I love RA to death (never used it much on Wii), but man it is just too much to set up sometimes.
For me it mostly comes down to trying to tweak latency settings as far as I can, which usually leads me to one or more roadblock, which when solved means some compromise.
I have had a lot of trouble with Vulkan rendering working properly, along with input mapping sometimes forgetting all of my controllers.
But when you have everything set up, it is really sweet.