I’ve been able to play around a bit with X68000 emulation this weekend.I tried a few games in px68k and they seemed to boot and run okay, Castlevania, Gradius, and R-Type 2 were the only ones I tried. The main issue I had with the Retroarch core was that the interface is very clunky for selecting discs and some hotkeys tie back to Retroarch and and mess with the game unexpectedly.
XM6 also ran all of those fine. It had much better sound once I turned on MIDI emulation, and had a ton more options for controller and system specs. The standalone nature also allowed for a better interface so I ended up using it mostly.
Given the additional work involved in emulating an old PC like this, I will have to seek out the very best exclusives, while going for console ports wherever I can. I will continue playing around with the emulators to see if I can streamline loading and dialing things in for games, and I look forward to seeing what this has system to offer.